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Bacterial CORE-nanotube organelle

The Hebrew University of Jerusalem

Initiated 1.4.2019

PUBLICATIONS

Selected publications:

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Parallel evolutionary trajectories rewire enteropathogenic Escherichia coli adhesion to restore host attachment. Noam Yedidi, Klil Cohen-Yaron, Miriam Ravins, Michal Bejerano-Sagie, Sigal Ben-Yehuda, Ilan Rosenshine. 2026, GUT MICROBES, VOL. 18, NO. 1, 2725431

Formation of a membraneless compartment regulates bacterial virulence
Aroeti et al., 2025
Nat Commun. 16(1):3834.

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Dormant bacterial spores encrypt a long-lasting transcriptional program to be executed during revival
Bing Zhou, Yifei Xiong, Yuval Nevo, Tamar Kahan, Oren Yakovian, Sima Alon, Saurabh Bhattacharya, Ilan Rosenshine, Lior Sinai, Sigal Ben-Yehuda. 2023
Mol Cell 22: 4158-4173.e7

The impact of Hfq-mediated sRNA-mRNA interactome on the virulence of enteropathogenic Escherichia coli, Pearl Mizrahi et al., 2021. Science Advances, doi: 10.1126/sciadv.abi8228

Control of type III secretion system effector/chaperone ratio fosters pathogen adaptation to host adherent lifestyle. Elbaz et al., 2019, mBio, e02074-19. doi: 10.1128/mBio.02074-19

A family of endonucleases blocks nanotube-mediated plasmid exchange. Venkadesaperumal Gopu , Saurabh Bhattacharya, Michal Bejerano-Sagie, Mei Zhuang, Yuval Nevo, Oren Yakovian, Bushra Shraiteh, Miriam Ravins, Manas Kumar Guria, Tamar Kahan, Boris Maček, Ilan Rosenshine, Sigal Ben-Yehuda. 2026
Nat. Microbiol. 11(4):960-975.

A bacterial host factor confines phage localization for excluding the infected compartment through cell division. Fiyaksel et al., 2025
Cell Reports 44(7):115994.

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Discovery of a Novel Inner Membrane-Associated Bacterial Structure Related to the Flagellar Type III Secretion System
Kaplan et al., 2022
J. Bacteriol 2022 Aug 16;204(8):e0014422.

Binding specificity of type three secretion system effector NleH2 to multi-cargo chaperone CesT and their phosphorylation, Yadav et al., 2021. J. Protein Sci. doi: 10.1002/pro.4210. n

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Pathogenic E. coli Extracts Nutrients from Infected Host Cells Utilizing Injectisome Components.
Pal et al., 2019.
Cell 77(3):683-696.

A Bifunctional T3SS-Effector Simultaneously Cleaves Host MAP Kinase and Inhibits PPM1A Phosphatase.
Yaakov Socol et al. 2026, Adv Sci . 28:e09702.

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Flagellar rotation facilitates the transfer of a bacterial conjugative plasmid
Bhattacharya S, Bejerano-Sagie M, Ravins M, Zeroni L, Kaur P, Gopu V, Rosenshine I, Ben-Yehuda S. 2025 EMBO J. Jan;44(2):587-61100320-0. Epub 2024 Dec 2.PMID: 39623141

Activation of the Type III Secretion System of Enteropathogenic Escherichia coli Leads to Remodeling of Its Membrane Composition and Function Zacharia et al., 2022 mSystems 7:e00202-22.

The bacterial metalloprotease NleD selectively cleaves mitogen-activated protein kinases that have high flexibility in their activation loop. Gur-Arie et al., 2020. J Biol Chem doi: 10.1074/jbc.RA120.013590

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A Ubiquitous Platform for Bacterial Nanotube Biogenesis.
Bhattacharya, Baidya et al., 2019.
Cell Reports 27(2):334-342

Uncovering phenotypic inheritance from single cells with Microcolony-seq.
Faigenbaum-Romm R, Yedidi N, Gefen O, Katsowich-Nagar N, Aroeti L, Ronin I, Bar-Meir M, Rosenshine I, Balaban NQ. 2025 Cell. ;188(19):5313-5331.

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Sensing for survival: specialised regulatory mechanisms of Type III secretion systems in Gram-negative pathogens
Yadav Manisha, Mahalashmi Srinivasan, Chacko Jobichen , Ilan Rosenshine and J. Sivaraman. 2024 Biol. Rev. 99, pp. 837–863. 837doi: 10.1111/brv.13047

Bacteria elicit a phage tolerance response subsequent to infection of their neighbors. Elhanan Tzipilevich Osher Pollak-Fiyaksel Bushra Shraiteh, Sigal Ben-Yehuda. 2022 EMBO J 41:e109247

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Donor-delivered cell wall hydrolases facilitate nanotube penetration into recipient bacteria. Baidya AK, Rosenshine I, Ben-Yehuda S
2020. Nature Commun 11(1):1938. doi: 10.1038/s41467-020-15605-1.nature.com

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